Mechanisms of epithelial patterning in the «Drosophila» ovary
Bibliographic record
Abstract
Patterning of the Drosophila eggshell requires the induction of dorsal fates in the follicular epithelium of the ovary, which will secrete this eggshell. These fates are induced by the localized activation of epidermal growth factor (Egfr) signaling mediated by its localized ligand Gurken (Grk), which restricts the acquisition of dorsal fates to the dorsal anterior domain of the epithelium. The generation of the complex pattern of fates along the dorsal-ventral (DV) axis has been proposed to be generated by the induction of a second round of Egfr signaling in the follicular epithelium by the late Grk-Egfr signaling. Along the anterior-posterior axis, the restriction of dorsal fates induction to the anterior of the epithelium has been proposed to be mediated by the restriction of Decapentaplegic (Dpp) signaling to the anterior of the tissue. However, some results from the literature cannot be explained by these two models, suggesting that the mechanisms leading to dorsal fates specification are not fully understood. Contrary to these two models, I have shown that a second round of Egfr signaling induced by Grk-Egfr signaling is not required to specify dorsal fates along the DV axis. Instead, my data support the hypothesis that the different levels of Egfr activity generated by the gradient of Grk are sufficient to generate the pattern of fates along the DV axis. Furthermore, my results show that Dpp signaling is not required to restrict dorsal fate acquisition to the anterior of the tissue. Rather, my results suggest that the restriction of competence to induce dorsal fates to the anterior of the epithelium depends on the generation of a posterior refractory fate. My results suggest that it is the absence of the expression of the transcription factor Mirror (Mirr) in response to ectopic Egfr signaling in the posterior domain that restricts dorsal fates acquisition to the anterior domain. Taken together, my results suggest that the competence to express Mirr in the posterior domain is dependent on the early induction of Egfr signaling in this domain. Since only the dorsal-anterior domain is exposed to late Grk-Egfr signaling, Mirr expression is restricted to this domain.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".