Morphological classification of soft-shell clam, Mya arenaria, hemocytes: Phenotypic description of hemic neoplasia
Bibliographic record
Abstract
In Atlantic Canada, hemic neoplasia (HN) has a negative impact on aquaculture and fisheries of the soft-shell clam, Mya arenaria. HN is a cellular disorder that morphologically and functionally alters the hemocytes. These abnormal hemocytes are found proliferating in the hemolymph and infiltrating tissues. Cells described as neoplastic are larger with a high nucleus to cytoplasm ratio compared to normal hemocytes. Although the morphology and behavior of neoplastic cells has been described, information regarding the characteristics of normal hemocytes in the soft-shell clam is lacking. The present study used cytology and transmission electron microscopy to characterize 5 types of hemocytes in clams. Hemolymph samples of normal clams had a mean differential hemocyte count of 62.6% agranular and 34.7% granular cells. Evaluation of the normal hemocytes provided descriptive information that was then useful for recognizing neoplastic cells. Two types of neoplastic cells and intermediate forms were observed at various levels of disease intensity. This study proposes criteria for recognizing neoplastic cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".