The role of the Prorenin Receptor in cancer progression
Bibliographic record
Abstract
Prostate and breast cancers (PCa and BC) impact the highest number of men and women, respectively, in Canada and the United States every year.One of the most frequently deleted or mutated genes in human PCa and BC is the PTEN gene.The phosphatase and tensin homolog (PTEN) protein plays a critical role in controlling cell growth and in ensuring non-malignant cell function.The loss of PTEN leads to changes that occurs in the cell.Changes in the levels of PTEN-targets may lead to oncogenic activities.In chapter 2, we show that PTEN loss in PCa cells leads to the upregulation of the Prorenin Receptor (PRR).PTEN regulation over PRR suggests that PRR may aid in tumorigenic activity upon tumor onset.PRR is an essential component of the vacuolar ATPase (V-ATPase) complex.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".