The role of the T-box transcription factors Midline and H15 during epidermal growth factor receptor mediated epithelial patterning in «Drosophila melanogaster»
Bibliographic record
Abstract
Axis specification in the Drosophila eggshell is achieved through localized activation of the epidermal growth factor receptor (EGFR) in the follicular epithelium by its ligand, Gurken (Grk), during oogenesis.Early activation of EGFR specifies posterior fates in the follicular epithelium.However at mid-oogenesis, graded EGFR activation in the dorsal anterior region of the epithelium will specify the dorsal anterior follicular cell fates.Recently we have shown that early EGFR signalling induces the expression of Midline and H15.These T-box transcription factors confer a molecular memory in posterior cells, preventing them from being specified as dorsal anterior follicle cells during the second phase of EGFR signalling.However the mechanism by which Midline and H15 restrict cellular response to EGFR at mid-oogenesis is not known.Furthermore, I would like to start off by first thanking my supervisor, Dr. Laura Nilson, who has been instrumental in shaping me as a scientist and an individual throughout both my undergraduate and graduate degrees.From the very beginning, she saw potential in me and encouraged me to work on challenging problems, taking the time to discuss and troubleshoot my ideas constructively.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".