USING MACHINE LEARNING TECHNIQUES FOR FINDING MEANINGFUL TRANSCRIPTS IN PROSTATE CANCER PROGRESSION
Bibliographic record
Abstract
Prostate Cancer is one of the most common types of cancer among Canadian men. Next generation sequencing that uses RNA-Seq can be valuable in studying cancer, since it provides large amounts of data as a source for information about biomarkers. For these reasons, we have chosen RNA-Seq data for prostate cancer progression in our study. In this research, we propose a new method for finding transcripts that can be used as genomic features. In this regard, we have gathered a very large amount of transcripts. There are a large number of transcripts that are not quite relevant, and we filter them by applying a feature selection algorithm. The results are then processed through a machine learning technique for classification such as the support vector machine which is used to classify different stages of prostate cancer. Finally, we have identified potential transcripts associated with prostate cancer progression. Ideally, these transcripts can be used for improving diagnosis, treatment, and drug development.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".