Associations Among Self-Reported Tick-Borne Disease Symptoms, Treatments & Diagnoses
Bibliographic record
Abstract
In eastern Canada, deer ticks (Ixodes scapularis) carry a variety of bacterial (Borrelia burgdorferi, Anaplasma, Ehrlichia, Rickettsia) and protozoan pathogens (Babesia) that are responsible for more disease in humans than any other arthropod vector. While most known tick borne diseases (TBD) in Canada are treatable, misdiagnosed and untreated infections can cause debilitating symptoms, many of which are non-specific and can be mistaken for other diseases. Using quantitative models, the goal of my thesis is to investigate whether tick-borne diseases cause syndromes (e.g., groups of symptoms which consistently occur together). An anonymous cross-sectional survey was disseminated online via the Qualtrics software package to survey age, gender, blood test results, symptom profiles, and chronic health conditions. Recruitment was focused on the Kingston-Ottawa corridor because it is a Lyme disease hotspot in Canada, but inclusion criteria included anyone with a self-reported tick bite. This resulted in 1248 unique submissions, 301 of which self-reported a tick-borne disease. On average, participants who reported a Lyme disease diagnosis along with one or more secondary co-infections presented with more symptoms and a longer time to diagnosis than participants with Lyme disease alone. I used supervised machine learning to model self-reported symptoms while accounting for demographics, clinical tests, and chronic health conditions. A Regularised Discriminant Analysis of 13 binary symptoms was 86.7% accurate at distinguishing individuals with TBD from those without TBD and correctly classified participants with 72.8% accuracy into self-reported diagnoses grouped into four categories: Lyme disease, Lyme disease with one or more co infections, other tick-borne disease, and no diagnosed disease. To model how healthcare practitioners might diagnose disease, I used hierarchical logistic regressions to identify self reported factors that predict diagnosis. Skin rash and blood tests were predictive of all three diagnosis categories, accounting for 41-61% of the variation in TBD diagnosis predictions. Participants with chronic health conditions (cardiovascular, rheumatological, and central nervous system disorders) were less likely to receive TBD diagnoses, which is consistent with misdiagnosed disease. This research shows that patients’ TBD symptom profiles can be used in a collaborative scientific approach to improve diagnosis and knowledge translation in the domain of TBD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".