Abnormality of Serum Lipids are Independently Associated \nwith Increased Serum Calcium Level in the Adult \nNewfoundland Population
Bibliographic record
Abstract
Some epidemiological evidence shows a link between abnormality of lipid profiles and variations in serum calcium. However, it is unknown whether this association resulted from confounding factors. The present study was designed to investigate the relationship between serum lipids and calcium. Serum calcium was corrected for albumin. Major confounding factors including age, gender, medications, menopause, parathyroid hormone (PTH) and 25-OH-vitamin D status were controlled in analyses. A total of 1907 adult subjects from the province of Newfoundland and Labrador (NL), Canada participated in the study. Significant positive correlations were detected between serum total cholesterol and high density lipoprotein-cholesterol (HDL-c) with variations of serum Ca ++ in both genders (p < 0.05-0.0001). Significant positive correlations were additionally detected between triglycerides (TG) and low density lipoprotein-cholesterol (LDL-c) with Ca ++ in women only (p < 0.0001) in partial correlation analyses. Similar significant results were detected in both females and males not taking any medication. Analyses were performed based on menopausal status as well. Significant correlations were seen in both pre- and post-menopausal women but higher correlation coefficients were observed in pre-menopausal women as compared to post-menopausal women. Subjects with low calcium levels had the lowest concentration of total cholesterol, TG, HDL-c and LDL-c, while subjects with high calcium levels had the highest concentration of all four markers in women. The significant associations between cholesterol, TG and LDL-c and serum Ca ++ remained after calcium was adjusted for 25-OH-vitamin D and PTH. Our results indicate that the abnormality of serum lipid profiles are significantly correlated with altered serum Ca ++ levels independent of age, obesity status, medication, phosphorus, magnesium, 25-OH-vitamin D and PTH.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".