Blood Pressure Responses to Physical and Mental Challenges in Adolescent Males and Females
Bibliographic record
Abstract
Enhanced blood pressure (BP) reactivity from stressors predicts hypertension, a disease more common in men than women throughout their reproductive age. Visceral obesity and genetic predisposition are major risk factors for hypertension. Here, we investigated whether visceral fat (VF) and one of the best-established loci of hypertension, CYP17A1, contribute to the sex difference in BP reactivity. In a community-based sample of 596 adolescents, we measured beat-by-beat BP during posture and math-stress tests, quantified visceral fat with magnetic resonance imaging, and genotyped all subjects at CYP17A1. Adolescent males versus females demonstrated greater BP reactivity to physical and mental stressors. In males but not females, VF was associated with higher BP reactivity to active standing and a specific variant of CYP17A1 was associated with higher BP reactivity to math stress. VF and CYP17A1 contribute to the observed sex-differences in BP reactivity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".