The clinical efficacy of ligustrazine in the treatment of knee osteoarthritis
Why this work is in the frame
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Bibliographic record
Abstract
Objective: To investigate the efficacy of ligustrazine in the treatment of mild and moderate knee osteoarthritis. Methods: This prospective study recruited 69 patients with knee osteoarthritis, who were randomly divided into a control group (n=34) and a treatment group (n=35). The patients in the control group were injected with hyaluronic acid in their joint cavities for 6 weeks. Based on the treatment in the control group, the patients in the treatment group took ligustrazine phosphate tablets orally for 6 weeks. The clinical efficacy and the patients' Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were observed before and after they were treated. The changes in the TNF-alpha, IL-1, IL-6, and MMP-13 levels in the joint fluid were measured. Results: After treatment, the efficacy of the treatment in the treatment group was better than the efficacy in the control group (P<0.05). The patients' WOMAC scores in the treatment group were better than the patients' scores in the control group after they were treated, but there was no significant difference (P>0.05). The patients' IL-1 and IL-6 levels in the treatment group were higher than the levels in the control group (P<0.01). The incidence of adverse reactions in the treatment group was lower than it was in the control group (P<0.05). Conclusion: Ligustrazine has a good clinical efficacy in the treatment of mild and moderate knee osteoarthritis and can improve the condition of knee joint activity and effectively reduce the levels of IL-1 and IL-6 in joint fluid as well as reduce the incidence of adverse reactions, indicating that ligustrazine can be used as a safe and effective treatment.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it