Characterisation of monolysocardiolipin acyltransferase activity
Bibliographic record
Abstract
Cardiolipin (CL) is a unique phospholipid synthesised exclusively in the mitochondria where it is also mainly localised. Monolyso-CL acyltransferase is the enzyme responsible for re-acylating monolyso-CL to CL once a phospholipase A has removed one of the fatty acid tails. Because of CL's role in activating enzymes involved in energy metabolism, we investigated the effect of insulin on monolyso-CL acyltransferase activity and the composition of CL acyl groups. We hypothesised that some of the alterations in mitochondrial function may be due to the alteration in CL remodelling activity. Sprague-Dawley (SD) rats were treated with insulin (i.p. 12 U/rat) for 5 or 26 days. The hearts were then isolated and the mitochondrial fractions were collected. These mitochondria were assayed for monolyso-CL acyltransferase activity. In addition, streptozotocin-induced, diabetic SD rats were injected with saline for 5 days and the heart mitochondrial monolyso-CL acyltransferase activity was measured. The CL molecular species was examined. The characteristics of monolyso-CL acyltransferase activity from rat heart mitochondria were studied. In other experiments, the activity of monolyso-CL acyltransferase was localised using rat liver mitochondria. (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".