Disease resistance in arabidopsis, starring TGA2 and also featuring NPR1
Bibliographic record
Abstract
Systemic acquired resistance (SAR) is a long-lasting, broad-spectrum disease resistance that arises throughout a plant, including non-infected tissue, upon localized exposure to a microbe that causes necrosis. Induction of SAR is accompanied by the accumulation of salicylic acid (SA) and is ultimately characterized by the upregulation of Pathogenesis-Related (PR) genes, including the SAR marker gene PR-1. Direct transcriptional control of PR-1 is governed by the TGA2 clade of transcription factors. TGA2, the archetypical member of this clade, demonstrates a unique dichotomy in that it is essential for mediating the repression of PR-1 in resting tissues, yet is also a requisite for activating this gene in SA-stimulated cells. TGA2 is at all times positioned on the PR-1 promoter and constitutes a point of integration for the genetic regulatory information, including that transmitted by transcriptional cofactors, most notably Nonexpresser of Pathogenesis-Related (PR) genes 1 (NPR1). Although the coactivator NPR1 is recognized as THE key regulator of PR-1 gene expression, activation of PR-1 is contingent upon its incorporation into a transactivating enhanceosome complex nucleated by TGA2.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".