Efficacy and safety of low dose compound betamethasone in the treatment of mild knee osteoarthritis
Bibliographic record
Abstract
Objective: To investigate the efficacy and safety of intra-articular injection of low-dose \ncompound betamethasone in the treatment of mild knee osteoarthritis. Methods: From \nSeptember 2018 to December 2019, 90 patients with mild knee osteoarthritis were divided into \ncomplete dose group and low dose group according to the treatment sequence, 45 cases in each \ngroup. The complete dose group was treated with intra-artiular injection of betamethasone(1ml) \nand sodium hyaluronate(2ml), once a week, three times as a course of treatment. The low \ndose group was treated with intra-artiular injection of betamethasone(0.3ml) and sodium \nhyaluronate(2ml), once a week, three times as a course of treatment. Lysholm scores、 the \nWestern Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual \nanalogue scale (VAS) were compared between the two groups before and after treatment, and \nthe efficacy and safety of the two groups were evaluated. Results: 80 patients were followed \nup with an average of (4.96 ± 1.50) months ranging from 3 to 8 months, and 10 cases (11.11%) \nwere dropped out, including 2 cases in the complete dose group, 2 cases in the midway \nwithdrawal group, and 1 case in the treatment course less than the treatment course; 3 cases \nin the low dose group lost the follow-up, and 2 cases dropped out. Compared with that before \ntreatment, Lysholm scores were significantly improved, WOMAC scores and VAS scores were \nsignificantly decreased in the two groups at 3 weeks, 6 weeks and 12 weeks after treatment \n(P < 0.001). The Lysholm scores of low dose group were78.10 ± 2.16, 86.78 ± 2.55, 80.90 \n± 2.26, WOMAC scores were 61.00±1.38, 39.03±1.98, 45.76±1.66 and VAS scores were \n2.23±0.89, 0.78±0.73 and 1.05±0.85 in low dose group at 3 weeks, 6 weeks and 12 weeks after \ntreatment. There was no significant difference between the two groups (P > 0.05). No drugrelated \nadverse reactions occurred in both groups. Conclusion: The curative effect of low dose \ncompound betamethasone intra-articular injection in the treatment of mild knee osteoarthritis is \nequivalent to that of complete dose compound betamethasone. It can improve the function and \nsymptoms of knee joint, and is safe and effective.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".