Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The genus Mycobacterium comprises a variety of highly successful intracellular pathogens. Mycobacterium tuberculosis is the causative agent of tuberculosis (TB) in humans and currently infects one third of the world's population. Mycobacterium avium ssp. paratuberculosis is the established cause of Johne's disease in ruminants and is epidemiologically associated with Crohn's disease (CD) in humans. Both TB and CD are complex genetic diseases for which immunological pathways associated with disease susceptibility or resistance have been identified based on human genetic studies. Common polymorphisms in NOD2 have recently been described to predispose to CD. NOD2 encodes a receptor of the Nod-like receptor (NLR) family involved in mediating innate immunity upon recognition of fragments of bacterial peptidoglycan (PGN), a structural component of most bacterial cell wall. CD-associated NOD2 polymorphisms were shown to abrogate this response. While recent studies have uncovered an important role of NOD2 for the recognition of mycobacterial species, the consequences and significance of this recognition remain obscure. The first part of the work presented in this thesis investigates the consequences of NOD2-mediated recognition on innate responses, adaptive immunity and resistance to mycobacterial infection. Using Nod2-deficient mice as a model to study CD-associated NOD2 mutations in humans, we show that the NOD2 pathway is critical for both innate and acquired anti-mycobacterial immunity. Impaired mycobacterial recognition at early time points following infection altered the immunopathology in the lungs and resulted in decreased survival of Nod2-deficient mice when virulent M. tuberculosis was given by aerosol. The second part of this thesis focuses on the biochemical basis of mycobacterial recognition by NOD2. The bacterial N-acetylmuramic acid hydroxylase (NamH) enzyme introduces a specific modification in PGN. We correlated the presence of this enzyme in mycobacteri
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it