Inquiro;

inquiro\nno. 1 | 2007\nThe University of Alabama at Birmingham\ninquiro no. 1 2007 \t \t \t \t \t The University of Alabama at Birmingham\nCopyright 2007\nThe rights to the papers published in this work are retained by the\nauthors. Authors may publish their work in any other media, with\nthe exception of another undergraduate publication.\nThis is an internal document of the\nUniversity of Alabama at Birmingham.\nFront cover art: Yu-Hui Huang\nYu-Hui is a senior majoring in biology and art studio.\nBack cover art: Kathy Baty\nKathy Baty is junior majoring in art studio.\nfrom the editor\ninquiro\nno. 1 | 2007\nabout i n q u i r o\nFounded and staffed by\nundergraduate students\nat the University of Ala-bama\nat Birmingham,\nInquiro is an annual\nresearch journal produced\nas an outlet for the pub-lication\nof undergraduate\nscientific research.\nUAB is an excellent\nundergraduate research\nuniversity, and with the\naddition of a journal such\nas Inquiro in which to\npublish their findings, the\npackage is complete. Any\nundergraduate student\nat UAB, as well as any\nstudent participating in\na summer program at the\nuniversity, is eligible to\nsubmit research.\nThe rights to every\npaper published in In-quiro\nare retained by\nthe author, leaving each\nindividual free to sub-mit\nto and publish in a\nlarger national journal\nor magazine. Students\nare invited to submit\nresearch papers, short re-ports\nderived from post-ers\nor research narratives\nthroughout the year.\nInquiro: to search; to know. Curiosity about\nthe natural world has been a defining trait of\nour species since the beginning of time. Ancient\ncivilizations all over the world developed\nmethods to harness the power of nature and\nto explain the mysteries of the universe. The\nhuman spirit of discovery has survived millennia\nand flourishes now more than ever before. As\nwe uncover the secrets of the human genome,\nthe laws of modern physics, and the delicate\nbalance of our environment, we embark on\nunprecedented journeys into the unknown.\nFurthermore, it is a journey which allows us to\nescape national borders, age differences, and\neven language barriers. This journey is for all\nhumanity.\nThree years ago, I began this journey for myself. As a sophomore\nbiology major, I knew the basics of genetics, chemistry, and biology,\nbut I never expected that I would have the expertise or knowledge\nto work on a research project. The day that I began work in UAB’s\nDepartment of Nephrology was a day filled with firsts: It was\nthe first time I had seen live cancer cells under a microscope. It\nwas the first time I had measured out a microliter of anything.\nIt was the first time I heard the terms FACS analysis and caspase\npathway. As I look back on my days in that lab, I realize how\nmuch that experience changed me: I was no longer just a college\nstudent; I had become a researcher. I wasn’t just studying biology; I\nwas discovering it!\nfrom the editor\nAs a senior nearing graduation, research has become one of my\npassions. Now working in a world-class immunology lab, I am at\nthe forefront of scientific inquiry. This experience is one that I share\nwith many UAB students across the disciplines. From field studies in\nAntarctica to journeys in outer space, UAB investigators have been\nrecognized on both national and global levels, creating an exciting\nenvironment in which to spark the interests of undergraduates.\nUAB, more than any other institution in the state, encourages\nstudents to participate in research, and students are certainly re-sponding.\nEach year, dozens of undergraduates begin working in\nresearch labs, with goals of an honors thesis, practical experience, or\neven a part-time job. Given the difficulty and quality of work that\nour undergraduates produce, it only makes sense that these students\nshould be given an outlet in which to feature their efforts. Although\nmany university departments hold research symposiums throughout\nthe year, it is rare for students to have the opportunity to display\ntheir work before peers and faculty from other disciplines, as well as\nto the university community as a whole. In light of this need, Inquiro\nwas born.\nWhile undergraduates may work in labs for a few semesters or\na summer, it is unusual for students to publish their work in inter-nationally\npeer-reviewed journals, simply due to time constraints.\nThis journal gives students the chance to experience the process of\nwriting and preparing a research paper for publication. While the\njournal isn’t “peer reviewed” in its purest sense, each paper is re-viewed\nby at least one faculty member, so that students get a feel for\nsubmission and revision process.\nThe concept of the undergraduate journal has previously been\nembraced by other universities such as Harvard, Columbia, and\nYale. With the inauguration of Inquiro, UAB students now have the\nopportunity ascend to the undergraduate publishing ranks with the\nbest and brightest students in the nation. Please join us as we blaze\nthe trail for the future of undergraduate research at the University of\nAlabama at Birmingham!\n—Suzanne McCluskey\nFounding Editor\ni n q u i r o s t a f f\nFounding Editor\nSuzanne McCluskey\nLayout/Design\nEditors\nJaymee Smith\nTaylor Nelson\nMatt Morton\nStaff Writers\nAlex Vaughn\nLarry Lawal\nChristina Ho\nBasil Bakir\nFelix Kishinevsky\nKelci Burckhardt\nShalini Vaid\nMichael Lester\nPratik Talati\nLette r f rom the Founding Editor 1\nScience News 5\nResearch Ethics 8\nResearch Narrative 10\nS h o r t R e p o r t s\nPhotoc atalyt i c Degradat ion of Indus t r ial\nDyes in UV- i r radiated Suspens ions of\nTitania Coated Glass Mi c roballoons 12\nIdent i f i c at ion of Proteins that Phys i c al l y\nInteract with the Ce l l Cycle Regulated\nUbiquitin Ligase G2E3 17\nSex Ratios Produced in the Kemp’s R idley\nRecover y Program 20\nInt ra- and Inter-Hemispheric\nSt roop Ef fect s 23\nHi s tologi c al Evaluat ion of Hat chl ing S ex\nRatios of Hawaiian Green Sea Turtles 27\nB i o l o g y\nFaculty I n ter view: Into the Antar c t i c\nwi th Dr. Char les Ams ler and Dr. James\nMcCl i ntock 32\nPapers\nHGF Is Released By Ischemic\nRenal Tissue 36\nTes t -Retes t Rel iabi l i t y of\nComputer i zed Dynami c\nPos turography in Chi ldren Wi t h\nand Without Cerebral Palsy 40\nProtein Expression and Methylation\nPat terns in Response to Glucos e\nDepletion in MCF-7 Ce l l s 47\ninquiro\nno. 1 | 2007\ncontents\nDetermining the S econd Vi r ial\nCoefficient ( B 22) by Se l f- Interaction\nChromatography (SIC ) 50\nFaculty I n ter view: Dr. L ar r y DeLuc as :\nThe First Optometrist in Space 55\nC h e m i s t r y\nFaculty I n ter view: Trac y Hami l ton:\nChemistry’s ver y own Renaissance Man 57\nPapers\nA Monte Car lo Inves t igat ion of\nDNA S eparat ion in the Ent ropi c\nTrap Device 59\nSt ruc tural Charac ter i zat ion of\nBaci l l u s anthraci s NAD+ Synthetas e\nby Limited Proteolys i s 64\nStudent Feature: Sonja Brooks :\nGoldwater Scholar 76\nM a t h\nPaper\nExplor ing the Var iance of the\nSquare Root of a Poi s son\nRandom Variable 77\nP h y s i c s\nFacul t y Inter view: An Inter view\nwith Dr. Renato Camata 80\nAbout the staff 83\nAcknowledgments 87\nSubmission Guidelines for 2008 88\ninquiro\nno. 1 | 2007\ncontents\nscience news\nWomen’s Wage in Academia A study\npublished in Academic Medicine suggests\nthat wage discrimination in science can\nbe corrected by aggressive administration\nintervention. The study, carried out in the\nUniversity of Arizona’s School of Medicine,\nshows that wages of women scientists with\ndoctorates in basic sciences went from 89%\nof their male counterparts to 97.6% after\ncorrective action by the University admin-istration.\nThe study relied on actual salary\nrecords instead of surveys. This, the authors\nargue, makes the study more reliable than\npast ones.\nUS Postdocs Stuggle to Find Faculty Slots\nPostdocs in the life sciences are struggling\nto move up in the academic hierarchy as\nthey find that tenured faculty slots at major\nresearch institutions are staying static even\nas the number of Ph.D’s in the life sciences\nare increasing. In 2007, nearly 7,000 Ph.D’s\nwere graduated by American universities,\nbut the number of Ph.D’s in the life sciences\nwith tenure stayed steady at 20,000 —the\nsame number as there were in 1981. This\nequates to a drop in tenured Ph.D’s in the\nlife sciences from 45% in 1981 to 30% to-day.\nAnalysts credit this trend to an increase\nin federal funding for biomedical research,\nwhich has been focused toward creating\ninfrastructure and not toward faculty.\nFabled “Arctic Passage” Not so Mythical\nClimate change is causing increased loss\nof ice mass in the northern waters of\nCanada. Analysts say this new passage\nmay eventually be a major route for world-wide\ntrade. Canadian claims to these waters,\nhowever, are not recognized by other\nnations.\nLargest Academic Conference Held in\nSan Diego The Society for Neuroscience\nannual meeting took place this November\nin San Diego. This conference, the largest\nacademic conference held in any academic\ndiscipline, welcomed over 25,000 attendees.\nMerck HIV Vaccine Fails A clinical trial of\na new HIV vaccine being run by Merck re-cently\nfailed, causing the pharmaceutical gi-ant\nto halt testing. Merck hoped the vaccine\nwould stimulate native immunity against\nHIV by the introduction of three synthetic\nHIV genes through a combination of three\nweakened strains of adenoviruses, a large,\nunenveloped double-stranded viral family.\nThe trial tested the vaccine on a population\nof approximately 700 people at high risk for\nHIV transmission. Both the comparison and\nexperimental groups experienced the same\nrate of HIV infection and the experimental\ngroup tested for similar levels of bloodborne\nHIV as did the comparison group.\nWomen’s Wages, Postdoc Woes, and Fabled Arctic Passage\nOpens in Northern Canadian Waters\nBasil Bakir\ninquir

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