Qualidade de vida relacionada à saúde em pacientes acometidos por doença inflamatória intestinal tratados com terapia biológica
Bibliographic record
Abstract
Inflammatory bowel diseases are becoming a major public health problem in Brazil and worldwide. Although their incidence is relatively low, studies show that young people of working age are affected by this disease characterized by periods of activity and remission amending of impactful quality of life. The conventional medical treatment includes the use of immunosuppressive and immunoregulatory agents.It stands out among these treatments biological therapy, represented by the class of tumor necrosis drugs (anti-TNF α). Objective: To correlate the clinical response to the quality of life of patients with inflammatory disease treated with biologic therapy. Methods: A prospective longitudinal study conducted at the Hospital of the Botucatu School of Medicine / UNESP, which evaluated 35 patients with inflammatory bowel disease using biological therapy through Inflammatory quality of life questionnaires Bowel Disease Questionnaire(IBDQ) and Crohn's disease activity index (DC), and CDAI score of Mayo for Ulcerative Colitis and Montreal Rating disease at weeks 0, 14,30,54 Results: 42,8% of the study population were female, 57,2% male, 94,3% white, 17,1% were smokers, and 77,1% were affected by Crohn's disease (CD) and 22.8% Colitis Colitis (UC). Of these patients 65, 7% made use of Infliximab and 34,3% of Adalimumab. The mean disease duration was 6,1 years (± 5,0). Clinical remission with symptom improvement and healing of the intestinal mucosa was achieved by 80% of patients. Perianal manifestations were observed in 44,4 %%, 25,7% required hospitalization, surgery 25,7%, 2,9% progressed to death. In responding patients showed a statistically significant improvement in all the applied life quality scores
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.002 | 0.003 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.012 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".