The prostaglandin Eâ EPâ receptor : the elucidation of agonist mediated receptor regulation and a novel therapeutic role for an EPâ agonist in allergic lung inflammation
Bibliographic record
Abstract
Prostaglandin (PG) E2 is involved in a number of physiological and path op hysiologicaI events in many tissues. PGE2 mediates its actions through interaction with specific plasma-membrane G-protein coupled receptors (GPCR's). There are four subtypes of PGE2 receptors: EP1, EP2, EP3 and EP4, classified by their different pharmacological profiles and signal transduction pathways. EP4 agonists have potential therapeutic benefit in diseases such as osteoporosis (EP4 mediates the bone anabolic actions of PGE 2), but possibly in other areas such as asthma. A characteristic feature of GPCR's is their ability to undergo agonist-induced desensitization and this response may limit the therapeutic utility of agonists due to tachyphylaxis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.011 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".