Characterization of a novel endogenous steroid, estradienolone (ED), in human pregnancy
Bibliographic record
Abstract
Estradienolone (ED, 17beta-hydroxy-[1,5]-estradien-3-one) is a novel steroid hormone identified in pregnant women. It is an isomer of estradiol which binds the progesterone receptor and sex hormone binding globulin with high affinity. Since levels of ED remain high throughout pregnancy and decrease in association with term or preterm labour, ED may be involved in the maintenance of pregnancy. The objectives of the present study were to, (i) purify ED from pregnancy samples in quantities sufficient for chemical analysis to confirm its structural features, and (ii) identify its binding proteins and receptors. Our results show that ED binds the novel methyltrienolone (R1881) binding protein of JEG-3 cells with higher affinity than any other natural steroids tested. Furthermore, ED is able to inhibit transcriptional activity of the estrogen-receptor-related receptors alpha and gamma, suggesting that ED may be the natural ligand of these orphan receptors. ED is also able to activate the xenobiotic receptor SXR. Chemical analysis of the fine structural features of purified ED is in progress.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".