Cyclic imines (gymnodimine, spirolides, pinnatoxins, pteriatoxins prorocentrolide and spiro-prorocentrimine)
Bibliographic record
Abstract
The cyclic imines group includes gymnodimine, spirolides, pinnatoxins, prorocentrolide and spirocentrimine. The presence of this group of compounds in shellfish was discovered because of their very high acute toxicity in mice upon i.p. injections of lipophilic extracts. When present at elevated levels, they rapidly kill mice, and their presence may interfere with the MBA for OA, BTXs, and AZA groups. At sublethal doses, the mice recover rapidly. The toxic potential of the cyclic imines is much lower via the oral route. The regulatory significance of the cyclic imine toxins is still unclear. Although gymnodimine and spirolides are now known to commonly occur in microalgae and/or bivalve molluscs from several parts of the world (Canada, Denmark, New Zealand, Norway, Tunisia, the United Kingdom of Great Britain and Northern Ireland, and the United States of America), there have been no reports of adverse effects in humans.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".