Effects and Mechanisms of Methuosis Defined Through the Use of Indole-Based Chalcone Compounds in Human Glioblastoma Cells
Bibliographic record
Abstract
Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in adults.Full removal of the tumor by surgery is impossible, because it is highly invasive with finger-like tentacles.The poor prognosis and high recurrence rate attract tremendous attention for developing drugs to treat GBM.Currently, most chemotherapy agents aim to induce apoptosis in tumor cells.However, GBM cells harbor gene mutations that promote drug-resistance to apoptosis-inducing agents.Another challenge associated with the treatment of GBM is that the blood brain barrier (BBB) limits entry of drugs into intracranial tumors.Methuosis is a novel non-apoptotic cell death pathway associated with rapid cellular vacuolization from macropinosomes, late endosomes and autophagosomes, followed by massive cell death.Caspase inhibitors or suppression of autophagy do not prevent methuosis.Our lab has synthesized a series of indole chalcone compounds to induce methuosis in both parental and drug-resistant human GBM U251 cells.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.002 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".