The effect of timing of oseltamivir chemoprophylaxis in controlling influenza A H3N2 and influenza B outbreaks in long term care facilities in Manitoba, Canada, 2014-2015: a retrospective cohort study
Bibliographic record
Abstract
This study examines the effect of the timing of administration of oseltamivir chemoprophylaxis for the control of influenza A H3N2 and influenza B outbreaks among residents in long term care (LTC) facilities in Manitoba, Canada during the 2014-2015 influenza season. A retrospective cohort study was conducted of all LTC facility influenza A H3N2 outbreaks (n=94) and influenza B outbreaks (n=11) using a hierarchical logistic regression analysis. Delay of oseltamivir chemoprophylaxis was associated with increased odds of infection in both univariate (t = 5.41, df = 51, p < 0.0001), and multivariate analyses (t = 6.04, df = 49, p < 0.0001) with an adjusted odds ratio of 1.3 (95% CI: 1.2-1.5) per day for influenza A H3N2. No meaningful statistical analyses regarding influenza B could be conducted. From this study, we can conclude that the sooner chemoprophylaxis is initiated, the lower the odds of secondary infection with influenza in LTC facilities during outbreaks caused by influenza A H3N2 in Manitoba.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".