Factors Associated with Incidence of Cardiovascular Disease Among Patients with Rheumatoid Arthritis
Bibliographic record
Abstract
Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease (CVD). This thesis first explored risk factors affecting this association using a scoping review. The review included 33 cohort studies and showed that older age, male sex, co-morbid hypertension, diabetes, and/or dyslipidemia, the presence of rheumatoid factor (RF) and/or acute phase reactants, and glucocorticoids were associated with higher CVD incidence in RA patients. Using data from the Canadian Longitudinal Study on Aging (CLSA), Cox regression was used to explore whether RA increased CVD incidence among middle age and older individuals, accounting for various comorbidities, demographic, lifestyle and RA-related factors. RA patients experienced significantly more CVD incidence, compared to non-RA individuals (IRR = 1.69, 95% CI: 1.34 – 2.11). The stratified analysis showed that sex, age and education level were effect modifiers in the relationship between RA and CVD incidence.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.002 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".