Genetic markers of neurodegeneration: a role for 3-hydroxy -3-methylglutaryl-coenzyme A reductase in sporadic Alzheimer's disease
Bibliographic record
Abstract
Maintes preuves convergent aujourd'hui vers un métabolisme du cholestérol anormal dans la maladie d'Alzheimer (MA). D'autres constats suggèrent que les statines, ou inhibiteurs de la 3-hydroxy-3-méthylglutaryl coenzyme A réductase (HMGR), l'enzyme limitante de la voie de synthèse du cholestérol, protégeraient contre cette maladie. À partir d'une large cohorte de Canadiens français, nous démontrons qu'un polymorphisme du gène codant pour HMGR diminue fortement le risque de développer la MA, alors qu'un second constitue un facteur de risque influençant l'âge de début de la maladie. Ce dernier semble intervenir dans la formation d'enchevêtrements neurofibrillaires, l'une des marques neuropathologiques de la MA, ainsi que sur l'expression et les niveaux de protéines de HMGR dans le cortex frontal, l'une des régions gravement touchée par la maladie. L'implication de ce gène, et la voie métabolique s'y rattachant, dans le développement, et possiblement la progression, de la MA semble donc plus que probable.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".