METABOLIC STUDIES OF (E)-2-BENZYLIDENECYCLOHEXANONE
Bibliographic record
Abstract
The aim of this project was to examine the in vivo metabolism of the anti-cancer agent, '(E)-2-benzylidene-. cyclohexanone (31), which has been found to be effective against the in vitro KB (Eagle) culture tissue (i.e. a human carcinoma of the nasopharynx). Urine and feces samples collected after intra-peritoneal and oral administration of the unsaturated ketone (31) to male albino Wistar rats were extracted by two methods. Liquid-liquid continuous extraction (Schreiber et al., 1968) resulted in virtual 100% extraction efficiency, whereas a modified version of Curry's general extraction procedure (1969) offered only a 11.40% extraction efficiency. Intraperitoneal injections in doses of 400 mg/kg and 40 mg/kg showed minute amounts (i.e. 0.75%) being ex-creted via the urine as the unchanged ketone (31). A meta-bolite (i.e. C13H1802, molecular weight 206.1311) excreted via the urine was also observed. Examination of the feces samples yielded no indication of the unchanged ketone (31) and/or metabolite(s) being excreted. The size of the dosage level did not alter the amounts of unchanged ketone (31) or metabolite excreted. Oral administration of the unsaturated ketone (31) in doses of 40 mg/kg yielded more promising results than the intraperitoneal experiment. A total of 0.66% of unchanged ketone (31) was found to be excreted via the urine, a result very similar to that observed with the intraperitoneal route. However, two other suspected metabolites excreted via the urine, totalling approximately 8% of the administered dose, were also found. The feces samples showed no sign of (E)-2- benzylidenecyclohexanone (31) being excreted unchanged. However, three possible metabolites, accounting for approxi-mately 80% of the administered dose, were indicated. The unchanged ketone (31) and possible metabolites mentioned in the intraperitoneal and oral dosed experiments were isolated by thin-layer chromatography and gas chromato-graphy, and will be examined further by mass spectrometry for possible identification.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".