Morphogenesis of opaque form «Candida albicans» cells
Bibliographic record
Abstract
ABSTRACT We followed the localization of GFP-tagged myosin I (Myo5), septin (Cdc12) and rhodamin-stained actin during bud and shmoo formation in opaque-phase cells of Candida albicans, and monitored the mating-associated processes of cell fusion, zygote budding, septum formation, daughter cell development and the dynamics of nuclear migration and division. The localization of Myo5p, Cdc12p and actin during budding in opaque and white cells is similar. In pheromone-stimulated cells, these proteins localize in shmoos in patterns consistent with hyphal formation in white-phase cells. MTLa cells generate shmoos 5-7 hours earlier than MTLα cells in mixed populations. In the daughter cell generated after mating, Cdc12p, Myo5p and actin localize as they do under vegetative budding conditions. Intriguingly, isogenicity for the mating type locus is involved in the positioning of the nuclear division; in MTLa cells the nucleus divides within the mother cell up to 70% of the time, rather than across the mother-bud neck.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".