Pharmacological and nanotherapeutic modulators of glioblastoma and its microenvironment
Bibliographic record
Abstract
Glioblastoma multiforme is a devastating disease for which available treatments consistently fail.The current clinical standard, temozolomide, is ineffective in most patients due to resistance mechanisms such as the upregulation of DNA repair enzymes.The main objective of this thesis is to report on pharmacological and nanotherapeutic modulators of glioblastoma, focusing on 1) the mechanism of action of a novel histone deacetylase inhibitor (sahaquine), 2) combination treatments targeting tumor defenses and 3) effects on microglia and astrocytes in the tumor microenvironment.Histone deacetylase 6 inhibitors are promising therapeutic agents for glioblastoma due to their effect on cytoplasmic targets (cytoskeleton, kinase signalling) important for cancer invasiveness and growth.We explored the mechanisms of sahaquine, a novel hybrid molecule combining two FDA-approved drugs: primaquine and vorinostat.We showed sahaquine to be List of Abbreviations
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".