A population-based association study of toll-like receptor signaling pathway gene polymorphisms in chronic rhinosinusitis
Bibliographic record
Abstract
Chronic rhinosinusitis (CRS) is a common inflammatory condition of the sinonasal mucosa from its interaction with bacteria and/or fungi. The toll-like receptor (TLR) family plays an important role in innate immunity by recognizing distinct pathogen-associated molecular patterns. We evaluated single nucleotide polymorphisms (SNPs) in candidate genes from the TLR signaling pathway in 206 individuals with severe CRS and 200 controls. We also investigated the association between these SNPs and total serum IgE level. A total of 96 out of 104 SNPs were successfully genotyped. Although we could not confirm an association with CRS, 3 SNPs in the IRAK4 gene â rs1461567, rs4251513, and rs4251559 â were found to be associated with total serum IgE levels (p < 0.004). The finding was replicated in a second independent population with asthma, from the Saguenay-Lac-Saint-Jean region (p < 0.031). These results demonstrate a clear association between SNPs in the IRAK4 gene and serum IgE levels in patients with CRS and asthma.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".