Acute Transverse Myelitis in a Child Following Oral Live Polio Vaccine Administration
Bibliographic record
Abstract
Sergiy Kramarov,1 Liudmyla Palatna,1 Iryna Shpak,1 Iryna Seriakova,1 Liudmyla Zakordonets,2 Liudmyla Verbova,3 Oleksandr Molodetskyi,3 Liudmyla Myroniak,4 Tatiana Isayenko5 1Department of Pediatric Infectious Diseases, Bogomolets National Medical University, Kyiv, Ukraine; 2International European University, Kyiv, Ukraine; 3SI Romodanov Institute of Neurosurgery of the NAMS of Ukraine, Kyiv, Ukraine; 4SI Ukrainian Center of Maternity and Childhood of the national academy of medical sciences of Ukraine, Kyiv, Ukraine; 5SI National Research Centre for Radiation Medicine and Hematologic Oncology of the National Academy of Medical Sciences of Ukraine Kyiv, Kyiv, UkraineCorrespondence: Iryna Seriakova, Department of Pediatric Infectious Diseases, Bogomolets National Medical University, Degtyarivska Street, 23, Kyiv, 04119, Ukraine, Email ikovaliukh@ukr.netBackground: Transverse myelitis is an urgent medical problem all over the world. Acute transverse myelitis is more common in children than in adults. Postvaccinal transverse myelitis is a rare complication of vaccination. In vaccine-associated paralytic poliomyelitis, the virus mosaically infects the motor neurons of the anterior horns of the spinal cord, resulting in asymmetric paralysis of predominantly proximal muscles.Case Presentation: The case of acute transverse myelitis in a 12-year-old child corresponds to the existing definition of a vaccine-associated paralytic poliomyelitis case: a temporal relationship between the onset of flaccid paralysis and the administration of oral polio vaccine and the duration of paralysis. The child developed flaccid paralysis 18 days after (August, 2024) the administration of oral polio vaccine and persisted for more than 60 days from the onset of the disease. Vaccine virus type 3 was isolated from the feces. However, the child received 2 doses of inactivated oral polio vaccine and 1 dose of bivalent (types 1 and 3) oral polio vaccine before the disease. The child did not have an increase in the titer of antibodies in paired sera to polioviruses types 1 and 3. Spinal cord magnetic resonance imaging revealed an intramedullary focus with hyperintense MR signal on 2WI, 2FS at the level of the spinal cord cone (Th11-L2), which spread across the entire diameter and unevenly accumulated paramagnetic. These changes were characteristic of acute transverse myelitis.Conclusion: This article presents a clinical case of Acute transverse myelitis in a child after administration of live oral polio vaccine. We aimed to emphasize the importance of differential diagnosis of myelitis in a child who received OPV. This is important from the point of view of epidemiological surveillance of poliomyelitis and possible adverse reactions after vaccination.Keywords: acute transverse myelitis, oral polio vaccine, inactivated oral polio vaccine, vaccine-associated paralytic poliomyelitis, spinal cord, paralysis
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".