Differential Regulation of IgA+ B Cells in Vitro by Stromal Cells from Distinctive Anatomical Compartments
Bibliographic record
Abstract
B cell development is regulated by stromal cells that form a supportive microenvironment. Bone marrow (BM), spleen (Sp), and the gut lamina propria (LP) constitute distinct anatomical compartments that support B cell differentiation. In order to examine the effect of stromal cells on IgA+ B cells, I developed an in vitro system to co-culture gut LP, BM, or Sp-derived stromal cells with B cell progenitors to characterize the signals to generate IgA+ B cells. In this study, I characterized optimal conditions for the in vitro generation of IgA+ B cells. I found that gut LP stromal cells promote IgA+ B cell accumulation through producing soluble stimulatory factors. In contrast, BM and Sp stromal cells impaired IgA+ B cell accumulation in vitro by inhibiting proliferation and differentiation of IgA+ B cells. These observations provide new insights into how stromal cells from different anatomical locations shape IgA+ B cell responses.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".