Functional validation of the genetic architecture of «Salmonella» persistence in 129S6 mice and the impact of Ses1 (Nramp1) on the transcriptome of «Salmonella» enteritidis during chronic carriage
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Salmonella Typhimurium and Salmonella Enteritidis cause a foodborne disease resulting in gastroenteritis.To study the persistence of Salmonella during the late phase of infection, a mouse model was developed using C57BL/6J mice that clear the bacteria completely from the spleen and lymph nodes within 42 days post-infection and 129S6 mice that become chronic carriers.Linkage analyses using a cross between C57BL/6J and 129S6 mice led to the mapping of ten quantitative trait loci, Ses1 to Ses10, affecting Salmonella persistence in mice.In the females, Ses3 showed significant effects on bacterial clearance and two significant interactions between Ses1.2 and Ses4 and between Ses1.2 and Ses5.To functionally validate in vivo the interaction between Ses1.2 and Ses4 or
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it