Investigating the effects of acute oxidative stress on the expression, localization and activity of cell death regulatory protein BNIP3
Bibliographic record
Abstract
BNIP3 is a BCL2 family member that promotes cell death or survival depending on expression level and localization. During hypoxia BNIP3 levels increase and localize to mitochondria, inducing autophagic cell death. Although hypoxic regions are common in solid tumors, BNIP3 expression in these cells promotes cell survival and more aggressive disease. ROS may play a role in regulating cellular response to hypoxia and is known to induce autophagy. However, BNIP3’s role in regulating oxidative stress-induced cell death is unknown and the focus of this study. Effects of hydrogen peroxide exposure on expression, localization and function of BNIP3 were explored using HEK293, U87 and MEF cells. BNIP3 expression and colocalization with mitochondria increased after treatment, along with cell death. However, knockdown of BNIP3 provided minor protection, suggesting that BNIP3 is not required for cell death induced by acute oxidative stress. Overall, BNIP3 may regulate oxidative stress-induced cell death in some cells.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".