The inflammatory role of late gestation lung 1«(Lgl1)»
Bibliographic record
Abstract
Deficient alveolar maturation in bronchopulmonary dysplasia (BPD) is characterized by distal airspace enlargement, disruption of elastin fibers and goblet cell hyperplasia, which are further exacerbated by supplemental oxygen and/or mechanical ventilation at birth. Glucocorticoids (GCs) are known to stimulate alveolarization and were the preferred treatment for BPD. However, prolonged use of GCs provoke severe side-effects and is no longer recommended. Our lab cloned late-gestation lung 1 (Lgl1), a GC-induced, developmentally regulated, secreted glycoprotein that is speculated to play a role in early lung branching morphogenesis and as a modulator of alveolar formation. We demonstrate that Lgl1 is profoundly suppressed in our OVA-induced asthma model. Combined with our previous findings that associate a deficiency in Lgl1 with inflammation, we propose that Lgl1 is a multifunctional protein involved in early and late lung development in addition to its role in inflammation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".