The involvement of phospholipase A₂ (PLA₂ ) in acylation stimulating protein (ASP) signaling /
Bibliographic record
Abstract
Preliminary data suggests that the lipogenic factor Acylation Stimulating Protein (ASP), stimulates the activity of calcium-dependent phospholipase A2 (cPLA2) by increasing intracellular calcium levels [Ca2+]i and by activating extracellular-signal-regulated kinase 1/2 (ERK 1/2). The arachidonic acid (AA) generated by cPLA2 action appears to function as a second messenger in ASP signaling. ASP also blocks TG breakdown. The calcium-independent PLA2 (iPLA2) zeta has recently been identified as a novel TG-lipase in 3T3-L1 cells. Bromoenol lactone (BEL), a non-reversible iPLA2 inhibitor, has been shown to specifically inhibit the TG-lipase activity of this enzyme. Preliminary data demonstrates that BEL stimulates basal TG synthesis, likely by inhibiting TG breakdown. The effects of BEL in combination with ASP are non-additive, suggesting they act through the same pathway. Furthermore, ASP appears to inhibit 3H-AA release into the media in a concentration-dependent manner. We propose that ASP inhibits an iPLA2 isoform with TG-lipase activity, an effect that can be mimicked by BEL.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".