Interleukin-17A signalling in murine hematopoietic stem and progenitor cells promotes proliferation and monocytic-biased differentiation
Bibliographic record
Abstract
6 Statistical analysis and software 31 Chapter 4: Results 32 4.1 Human bone marrow hematopoietic stem cells express at RNA levels the IL17A-signalling components 32 4.2 The IL17A-signalling components are part of the changes associated with inflammation and aging in human bone marrow HSCs 34 4.3 Mouse bone marrow hematopoietic stem and progenitor cells express the IL17A receptor, which activates P38 and C/EBPß phosphorylation 37 4.4 IL17A ex vivo supplementation increases expansion of MPP3-and MPP4-like cells and promotes monocytic differentiation affecting hematopoietic repopulation in vivo 42 4.5 In mice, IL17A is present in the bone marrow microenvironment, and it is produced by immune cells within the bone marrow 49 Chapter 5: Discussion 53 Chapter 6: Conclusions 59
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".