Memory consolidation for a morphine conditioned place preference blocked by protein synthesis inhibition
Bibliographic record
Abstract
The protein synthesis inhibitors cycloheximide and anisomycin were administered during training in an attempt to block the consolidation of the memory for a morphine conditioned place preference. The systemic injection of 2.5mg/kg of cycloheximide post-training failed to block consolidation, though there was a trend towards an attenuated preference, however cycloheximide produced a conditioned place aversion if paired with one compartment. To examine the effect of more complete protein synthesis inhibition and reduce the aversive effects, the less toxic protein synthesis inhibitor anisomycin was infused into the lateral ventricles of the brain either pre-, post- or 3 hours following training. Post-training infusions of anisomycin blocked the formation of a conditioned place preference, while pre-training and 3 hours post-training infusions showed no significant effect over two conditioning pairings. It was concluded that drug conditioning in the place preference paradigm requires protein synthesis for memory consolidation as do other learning paradigms.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.021 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".