The role of smooth muscle myosin isoforms in a model of innate airway hyperresponsiveness /
Bibliographic record
Abstract
Airway hyperresponsiveness (AHR) is a key feature of asthma, characterized by exaggerated rate and extent of shortening of airway smooth muscle. Two isoforms of the smooth muscle myosin differ by the presence [(+)insert] or absence [(-)insert] of a 7 amino acid insert. The (+)insert exhibits a 2-fold greater ATPase activity and velocity of actin filament propulsion in the in vitro motility assay. The expression of these isoforms and other contractile proteins was quantified in the trachea of the Fisher and Lewis rat model of innate AHR. We found 95% greater mRNA and 45% greater protein expression of the (+)insert isoform in the trachea of the hyperresponsive Fisher animal (p<0.01), but no difference in other contractile proteins. A greater extent of myosin phosphorylation was also observed (55.1+/- d6.4 vs. 41.4+/-d6.1, p<0.01). These results suggest that in addition to greater myosin activation, an increased expression of the (+)insert isoform contribute to AHR.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".