The role of neuronal activity on radial glia behaviour in «Xenopus laevis» tectum
Bibliographic record
Abstract
Glia have been reported to integrate and propagate signals via a neuronal activity-dependent intracellular increase of calcium. In vitro studies have also reported that glia exhibit rapid structural motility. We have performed in vivo two-photon analysis of a morphologically identifiable population of radial glia in the optic tectum of Xenopus laevis tadpoles that spontaneous and neuronal activity-responsive calcium transients much like astrocytes in the mammalian brain. Using live imaging of EGFP-F-expressing individual glial cells in intact Xenopus tadpoles, we found that these radial glia rapidly extend and retract long, fine filopodia within the tectal neuropil. These filopodia interact with retinotectal synapses and their motility is modulated by neuronal NMDAR activation and NO signaling. Finally, we observed that natural visual experience drove both an increase in the rate of calcium transients and a change in filopodial dynamics in these radial glia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".