Experimental Assessment Of An Inactivated Vaccine Against Histoplasma Capsulatum Var. Farciminosum In Horses
Bibliographic record
Abstract
Epizootic lymphangitis is a chronic infectious disease of equids, caused by the dimorphic fungus Histoplasma capsulatum var.farciminosum, and characterized by inflammation of the lymphatic vessels and formation of purulent lesions.In Kazakhstan, the disease remains endemic due to geographic proximity and active trade with neighboring countries.The objective of this study was to evaluate the safety, immunogenicity, and stability of an experimental inactivated vaccine developed using H. capsulatum var.. farciminosum strain "8ZH".Two fungal strains ("8ZH" and control "T") were cultivated, and the biological properties, virulence, and antigenic activity were assessed.The optimal inactivation conditions using 0.05% beta-propiolactone and the most effective adjuvant formulation (10% Montanide Gel 01) were determined.The resulting formulation induced detectable antibodies by day 14 postvaccination in foals, with immunity lasting at least 12 months.Stability was confirmed under recommended storage conditions.This work represents a significant step toward developing a preventive measure against epizootic lymphangitis in horses in Central Asia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".