Mutation calls by SMM-Seq of MutaMouse male liver exposed to Benzo(B)Fluoranthene for 28 days
Bibliographic record
Abstract
MutaMouse males were exposed to five doses of Benzo(B)Fluoranthene (BbF) alongside vehicle controls by oral gavage for 28 days with a 3 day sampling time. Random whole-genome sequencing of liver DNA was performed using MutagenTech's SMM-Seq. Each sample was sequenced to roughly 200Mb. Data is single-nucleotide variants identified by SMM-Seq for 24 mouse liver samples. Variants identified by SMM-seq were contrasted against the single-nucleotide polymorphisms database (dbSNP) to remove known mouse variants. Additionally, germline variants were excluded through conventional whole-genome sequencing of matched samples at 20X depth. Mutation frequency (number of mutations divided by total read depth) is significantly increased by BbF at the top two doses compared to control. BbF increases proportions of C>A subtypes compared to control.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.005 | 0.003 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".