Impact of Prior Q-Wave Myocardial Infarction in Transcatheter Aortic Valve Replacement Patients With Reduced Ejection Fraction
Why this work is in the frame
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Bibliographic record
Abstract
Background: Coronary artery disease is prevalent in transcatheter aortic valve replacement (TAVR) patients, but the specific impact of prior Q-wave myocardial infarction (QWMI), a marker of transmural infarction, remains underexplored. This study evaluated the clinical impact of QWMI in TAVR patients with left ventricular ejection fraction (LVEF) < 50%. Methods: Multicenter study including 1172 consecutive patients undergoing TAVR with contemporary devices, stratified according to prior QWMI. The primary outcome was all-cause mortality or heart failure hospitalization (HFH) over a median follow-up of 3 (1-4) years. Secondary endpoints included changes in LVEF and independent predictors of adverse outcomes. Results: = 0.013) were independent predictors of adverse outcomes. Conclusions: Up to 1 out of 10 TAVR patients with reduced LVEF had prior QWMI, which was associated with impaired LVEF recovery, especially in those with anterior QWMI, and worse clinical outcomes at 3-year follow-up, largely driven by comorbidities. These findings underscore the importance of advanced preprocedural imaging, tailored therapeutic strategies, and integrated multidisciplinary care to enhance outcomes in this high-risk TAVR population.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it