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Record W7084061392 · doi:10.63676/9n1yrp67

The ‘ring of fire’ phenomenon in chronic wounds: A new insight using fluorescence imaging

2025· article· en· W7084061392 on OpenAlexaff

Bibliographic record

VenueInternational Journal of Tissue Repair · 2025
Typearticle
Languageen
FieldPsychology
TopicStress and Burnout Research
Canadian institutionsPrincess Margaret Cancer CentreUniversity Health Network
Fundersnot available
KeywordsDiabetic footFluorescence-lifetime imaging microscopyFoot (prosody)FluorescenceChronic woundClinical trial

Abstract

fetched live from OpenAlex

Aim: To describe the ‘ring of fire’ phenomenon observed during fluorescence imaging of chronic wounds. Methods: The Fluorescence Imaging Assessment and Guidance (FLAAG) trial evaluated 350 patients with a variety of chronic wounds. During the FLAAG trial, the investigators observed a phenomenon when wounds were imaged using the MolecuLight i:X imaging device: bacteria fluorescence aggregated at the margin of the wound. This was most pronounced in diabetic foot ulcers. The term ‘ring of fire’ was coined to describe this clinical observation. Results: Six representative patients taken from the FLAAG trial are presented to demonstrate the ‘ring of fire’ in a variety of wound types. This included three diabetic foot ulcers, two venous leg ulcers and a surgical site infection following lumbar back surgery. Conclusion: This is the first clinical report of this phenomenon. It highlights the importance of focusing on the wound edge when managing nonhealing wounds.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0020.001
Science and technology studies0.0010.002
Scholarly communication0.0010.002
Open science0.0010.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.403
Teacher spread0.373 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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