Survey on Antimicrobial Use in Laboratory Rodents in North America_ Mus musculus ^0 Rattus norvegicus_January 29^J 2025_03.21.xlsx
Bibliographic record
Abstract
We surveyed veterinarians certified by the American College of Laboratory Animal Medicine (ACLAM) in the United States and Canada. Responses showed that antimicrobial use is widespread and routine in laboratory rodent vivaria, consistent with reports from Australia, New Zealand, and other qualitative studies. Overall, 91.7 percent of respondents reported regular use, citing research-specific reasons such as induction of microbiome dysbiosis, prophylaxis in immunocompromised rodents, and gene induction. Commonly used drug classes included fluoroquinolones, third generation cephalosporins, and in some cases glycopeptides and imipenems, all considered critically important to human health. We also examined disposal practices for antimicrobials and contaminated substrates and found many vivaria dispose of these in sewerage or landfill without prior inactivation.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.010 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".