Management of Pediatric Chronic Hepatitis C with Crushed or Split Glecaprevir/Pibrentasvir: A Case Series From East Jeddah Hospital, Saudi Arabia
Bibliographic record
Abstract
Aisha M Alamri,1 Wijdan A Almehman,1 Ali M Albuhairy,2 Ayed A Alkatheeri,3 Yahya A Alzahrani3 1Department of Pediatrics, East Jeddah Hospital, Ministry of Health, Jeddah, 23816, Saudi Arabia; 2Department of Medical Microbiology, East Jeddah Hospital, Ministry of Health, Jeddah, 23816, Saudi Arabia; 3Drug Information Center, Department of Pharmacy, East Jeddah Hospital, Ministry of Health, Jeddah, 23816, Saudi ArabiaCorrespondence: Yahya A Alzahrani, Drug Information Center, Department of pharmacy, East Jeddah hospital, 23816 King Abdullah Road, Sulaymaniyah, Jeddah, 22253, Saudi Arabia, Tel +966557700178, Email Yalzahrani5@moh.gov.saPurpose: Glecaprevir/Pibrentasvir (GLE/PIB) is approved for chronic hepatitis C treatment in both adults and pediatric patients, no data regarding crushing this drug in pediatric populations. This case series evaluate the efficacy and safety of crushed or split GLE/PIB tablets in two pediatric patients at East Jeddah Hospital, Saudi Arabia.Patients and Methods: Two treatment-naïve pediatric patients with normal liver function received weight-based GLE/PIB for eight weeks. The first patient ingested crushed tablets with juice, while the second consumed divided tablets. Viral load, liver function, and coagulation profiles were monitored. Both patients achieved rapid viral suppression, with hepatitis C RNA undetectable or near the lower limit of quantification by day 14. Liver function tests improved, and no adverse effects were observed.Conclusion: This is the first case series of successful pediatric HCV treatment using crushed or Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals split GLE/PIB. This approach may expand treatment options in resource-limited settings where pediatric formulations are unavailable.Keywords: glecaprevir/pibrentasvir, crushed tablets, split tablets, direct-acting antivi-rals daas, Saudi Arabia, case series
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".