Annals Academy of Medicine Neuro-developmental Deficits in Early-treated CH—Roy Joseph Neuro-developmental Deficits in Early-treated Congenital Hypothyroidism
Bibliographic record
Abstract
About half a century ago, it was documented that severe neuro-developmental deficits were present in children with hypothyroidism started on treatment after 7 months of age.1 An IQ above 90 was obtained in only 10 of 22 children treated before that age. Almost a decade and half later, it was reported that if treatment was started before 3 months of age, 85 % had an IQ>85.2 Newborn screening for congenital hypothyroidism was thus initiated about 35 years ago with the primary goal of preventing the severe deficits found in treated hypothyroids. The outcome of the earliest cohort of patients diagnosed by screening was reported by Quebec Network who found that none had an IQ <85 and that the mean IQ at 12 and 18 months of age were 113 and 105 respectively.3 At 18 months of age the mean was significantly lower (105) than that of the
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.012 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".