Molecular Analysis of Metallo--Lactamase Gene blaSPM-1-Surrounding Sequences from Disseminated Pseudomonas
Bibliographic record
Abstract
The spread of clonally related carbapenem-resistant Pseudomonas aeruginosa producing the metallo--lactamase SPM-1 was found in Recife, Brazil. Upstream of blaSPM-1, a novel common region (CR4) was identified, comprising an open reading frame, orf495, whose product shares significant identity with putative recombinases, such as Orf513. CR4 may be responsible for mobilization and expression of blaSPM-1. During the last decade, several acquired carbapenem-hydro-lyzing enzymes have been identified in Pseudomonas aerugi-nosa, beginning with IMP-1 and derivatives, which are wide-spread in Japan (24, 25) and China (4) and are emerging in Europe and Canada (8, 13). Then, VIM-1 and VIM-2 enzymes were characterized, first in Italy and France (11, 22), respec-tively, but these enzymes are also highly prevalent in Korea and Greece (7, 14, 29). Recently a third member of acquired Ambler class B -lactamases, SPM-1, has been identified from a P. aeruginosa isolate in Sao Paulo, Brazil (28). The aim of this study was to analyze carbapenem-resistant P.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".