IRMA and RIA Compared for Assessing Dexamethasone Suppression of Corticotropln in Plasma, Alex M. Sharp,
Bibliographic record
Abstract
Dexamethasone (DM8) suppresses secretion of corti-cotropin (ACTH) by the pituitary gland and hence also suppresses cortisol production by the adrenal gland, an overnight dose of 1 mg being sufficient to suppress the pituitary-adrenal axis (1). The availability of a immuno-radiometric assay (IRMA) kit for ACTH from Nichols Insti-tute (San Juan Capistrano, CA 92675) prompted us to compare it with our in-house radioimmunoassay (RIA) for ACTH, with respect to its ability to detect ACTH suppres-sion. Our ACTH RIA uses an antibody from IgG Corp. (Nashville, TN 37211), a standard from Peninsular Labs. (Belmont, CA 94002), an ‘251-tracer from CIS (Sarclay, France), and a second antibody from Bio-R[A (Montreal, Canada H3M 3A2). To measure cortisol suppression, we used the RIA kit from Farmos (Turku, Finland), which measures cortisol directly in both plasma and urine. Plasma DM8 was measured by an in-house RIA with use of an antibody from Professor V#{233}csei(D partment of Pharma-
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.006 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.019 | 0.011 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".