Bibliographic record
Abstract
Hutchison/MRC Research Centre ovarian cancer, and its product is implicated in DNA Hills Road repair and transcriptional regulation. Here we identify Cambridge CB2 2XZ a protein, EMSY, which binds BRCA2 within a region United Kingdom (exon 3) deleted in cancer. EMSY is capable of silenc-3Genetic Pathology Evaluation Centre of the ing the activation potential of BRCA2 exon 3, associ-Department of Pathology and Prostate Center ates with chromatin regulators HP1 and BS69, and at the Vancouver General Hospital localizes to sites of repair following DNA damage. Department of Pathology, British Columbia Cancer EMSY maps to chromosome 11q13.5, a region known Agency, and the University of British Columbia to be involved in breast and ovarian cancer. We show Room 509, JBRC that the EMSY gene is amplified almost exclusively in 2660 Oak Street sporadic breast cancer (13%) and higher-grade ovar-Vancouver, British Columbia V6H 3Z6 ian cancer (17%). In addition, EMSY amplification is Canada associated with worse survival, particularly in node-4 The Wellcome Trust Sanger Institute negative breast cancer, suggesting that it may be of Hinxton, Cambridge CB10 1SA prognostic value. The remarkable clinical overlap be-
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.005 | 0.003 |
| Open science | 0.001 | 0.003 |
| Research integrity | 0.003 | 0.002 |
| Insufficient payload (model declined to judge) | 0.796 | 0.539 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".