CORRESPONDENCE Sudden Cardiac Death and Ventricular Arrhythmias Associated with Domperidone: Evidence Supporting Health Canada’s Warning
Bibliographic record
Abstract
potential risk of sudden cardiac death and sudden ventricular arrhythmia associated with domperidone, particularly for patients older than 60 years of age and those taking more than 30 mg of domperidone per day.1 Clinicians should consider the evidence supporting this warning when they are weighing the risks and benefits of domperidone therapy for their patients. Domperidone, a peripheral dopamine antagonist, has been used since the late 1970s as an antiemetic and for symptomatic management of gastrointestinal dysmotility.2,3 Its global regulatory status is highly variable, ranging from available without a prescrip-tion in many European countries to not approved for use in the United States. In most countries, such as Canada, a prescription is required. Domperidone, particularly the IV product that was removed from the Canadian market in the 1980s, is well recognized for its association with QTc prolongation, sudden
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.041 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.005 | 0.005 |
| Insufficient payload (model declined to judge) | 0.011 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".