Consecutive Cyclic Pentapeptide Modules Form Short Alpha-Helices that are Very Stable to Water and Denaturants**
Bibliographic record
Abstract
General. Fmoc-Asp(OAllyl)-OH and tetrakis(triphenylphosphino)palladium were obtained from Sigma-Aldrich (Sydney, Australia). Boc-Lys(Fmoc)-OH, Rink Amide MBHA resin and other L-amino acids were obtained from Novabiochem (Melbourne, Australia). Benzotriazol-1-yl-1,1,3,3-tetramethyluronium (HBTU) and benzotriazol-1-yloxy-tris(dimethylamino)-phosphonium (BOP) were obtained from Richelieu Biotechnologies (Quebec Canada). All other reagents were of peptide synthesis grade and obtained from Auspep (Melbourne, Australia). Peptide Synthesis. Ac-(KARAD)n-NH2, n=2 (4), n=3 (5). Peptides 4 and 5 were prepared by manual stepwise solid phase peptide synthesis using HBTU/DIPEA activation for Fmoc chemistry 1 on Rink Amide MBHA resin (substitution 0.78mmol.g-1, 0.5mmol, 648mg). Four equivalents of amino acid and eight equivalents of diisopropylethylamine (DIPEA) were employed in each coupling step (45mins). Fmoc deprotections were achieved with 3×5min treatments with excess 1:1 piperidine:DMF. Coupling yields were monitored by quantitative ninhydrin assay 2
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".