for Escherichia coli–Producing Extended-Spectrum b-Lactamases: Importance of Community Isolates with blaCTX-M Genes
Why this work is in the frame
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Bibliographic record
Abstract
A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum b-lactamase–producing Escherichia coli infections in the Calgary Health Region during the years 2000–2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population;). Seventy-one percent of subjects hadP!.01 community-onset disease. Patients aged 65 years (22.0 vs. 3.8 cases per 100,000 population per year; P!) and women (9.2 vs. 1.7 cases per 100,000 population per year; ) had significantly higher rates.0001 P!.0001 of infection. Polymerase chain reaction identified 23 (15%) of 157 isolates as positive for blaCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was indepen-dently associated with CTX-M–b-lactamases (odds ratio, 14.2; 95 % confidence interval, 3.69–54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk. The emergence of antimicrobial-resistant bacterial spe-cies in hospitals is widely recognized as one of the most important contemporary health care issues [1]. Gram-negative organisms producing extended-spectrum b-
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it