© 2000 Canadian Medical Association or its licensors
Bibliographic record
Abstract
An association between the risk of venous thromboembolism and a hypercoagulable state has been recognized for some years. More recent advances in thrombosis research and laboratory medicine have provided an ever-expanding list of specific laboratory anomalies that may predispose people to venous thromboembolism. This article will review hypercoagulability with emphasis on laboratory risk markers and will provide some practical guidelines concerning the potential usefulness and limitations of such data in the context of patient management. An overview of procoagulant and anticoagulant reac-Fig. 1: An overview of the coagulation pathway. tions is shown in Fig. 1, and the conditions that promote a hypercoagulable state are summarized in Table 1. Hemostasis involves a concerted and complex series of reactions, integrating vascular, endothelial cell, platelet and plasma factor responses that regulate thrombus formation. In response to injury, or other prothrombotic stimuli, rapid changes in vascular endothelial cells will lead to both the release of intracellular proteins that participate in the hemostatic process and an alteration of cell-surface properties, promoting a thrombogenic environment. Platelet adhesion and activation and concurrent activation of the
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.985 | 0.055 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".